Journal: PLOS ONE
Article Title: Sex- and region-specific cortical and hippocampal whole genome transcriptome profiles from control and APP/PS1 Alzheimer’s disease mice
doi: 10.1371/journal.pone.0296959
Figure Lengend Snippet: Overview of the sex- and region-specific upregulation of DEGs in the four APP/PS1 subgroups. This table illustrates all upregulated DEGs (FC > 1.5) from APP/PS1 microarray analysis. DEGs that are upregulated only in one APP/PS1 subgroup are highlighted in red, those exhibiting enhanced transcript levels in two subgroups are marked in green. Increased transcript levels in three subgroups are marked in ocher, those in all four subgroups are highlighted in yellow. The table elicits the complex sex- and brain region specific profile of upregulated DEGs.
Article Snippet: Key features of the SurePrint G3 Mouse Gene Expression v2 8x60K Microarray chip (Agilent Technologies Germany GmbH & Co. KG, Germany) include up-to-date content sourced from RefSeq, Ensembl, RIKEN, UniGene, and GenBank databases to provide full coverage of the mouse transcriptome, wide dynamic range of over 5 logs to ensure detection of low and high expressors for the most biologically relevant data and the possibility to proceed with one or two colors based on experimental needs.
Techniques: Microarray